cancer
aar Authors Title Source Topics abstract pubmedtext fulltext
2002 Truman BI, Gooch BF, Sulemana I, Gift HC, Horowitz AM, Evans CA, Griffin
SO, Carande-Kulis VG
Reviews of evidence on interventions to prevent dental caries, oral and pharyngeal cancers, and sports-related craniofacial injuries. Am J Prev Med 2002; 23(1 Suppl): 21-54 Cancer Caries Trauma This report presents the results of systematic reviews of effectiveness, applicability, other positive and negative effects, economic evaluations, and barriers to use of selected population-based interventions intended to prevent or control dental caries, oral and pharyngeal cancers, and sports-related craniofacial injuries. The related systematic reviews are linked by a common conceptual approach. These reviews form the basis of recommendations by the Task Force on Community Preventive Services (the Task Force) about the use of these selected interventions. The Task Force recommendations are presented in this supplement Medline
2001 David LA, Sandor GK, Evans AW, Brown DH Hyperbaric oxygen therapy and mandibular osteoradionecrosis: a retrospective study and analysis of treatment outcomes J Can Dent Assoc 2001; 67(7): 384 cancer


2001 Milligan S, McGill M, Sweeney MP, Malarkey C Oral care for people with advanced cancer: an evidence-based protocol Int J Palliat Nurs 2001; 7(9): 418-26 cancer


2001 Sutherland SE, Browman GP Prophylaxis of oral mucositis in irradiated head-and-neck cancer patients: a proposed classification scheme of interventions and meta-analysis of randomized controlled trials Int J Radiation Oncol Biol Physics 2001; 49(4): 917-930 Cancer Medicine Mucosa PURPOSE: To identify, classify, and evaluate agents used in the prophylaxis of oral mucositis in irradiated head and neck cancer patients. METHODS: Data sources included multiple databases and manual citation review of relevant literature. Based on the eligibility criteria, 59 studies were independently reviewed by two reviewers. Forty-two studies were included in the classification scheme, of which 15 met the criteria for inclusion in the meta-analysis. Data were extracted by duplicate independent review, with disagreement resolved by consensus. RESULTS: Overall, the interventions reduced the odds of developing severe oral mucositis, when assessed by clinicians, by 36% (OR: 0.64; 95% CI: 0.46, 0.88). Subgroup analysis suggested that only the narrow-spectrum antibacterial lozenges were effective (OR: 0.45; 95% CI: 0.23, 0.86); however, the power of the aggregated data in the other classes may have been insufficient to detect differences. When the outcome was assessed by patients, no significant difference was seen in the outcome between the treatment and the control groups (OR: 0.79; 95% CI: 0.56-1.12). CONCLUSIONS: Overall, interventions chosen on a sound biologic basis to prevent severe oral mucositis are effective. In particular, when oral mucositis is assessed by clinicians, narrow-spectrum antibiotic lozenges appear to be beneficial. Methodologic limitations were evident in many of the studies. Further research using validated measurement tools in larger, methodologically sound trials is warranted. Medline Elsevier
2000 Gray M, Gold L, Burls A, Elley K A The effectiveness of toluidine blue dye as an adjunct to oral cancer screening in general dental practice West Midlands Development and Evaluation Service Report Birmingham: University of Birmingham 2000; 24: 1-40 Cancer
- WMDE
2000 Blanas N, Freund B, Schwartz M, Furst IM Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000; 90(5): 553-8 Cancer OBJECTIVES: To clarify the natural history of the odontogenic keratocyst (OKC) and to evaluate treatments with respect to the likelihood of recurrence. STUDY DESIGN: A systematic review of the literature was completed pertaining to the treatment and prognosis of the OKC. Each investigation was evaluated based on 4 inclusion criteria. Each study that met the 4 inclusion criteria was then evaluated based on 8 standards. RESULTS: Of 2290 citations reviewed pertaining to the OKC, 14 investigations were found to meet the 4 inclusion criteria. Resection was found to have the lowest recurrence rate (0%) but the highest morbidity rate. Simple enucleation was reported to have a recurrence rate of 17% to 56%. Simple enucleation combined with adjunctive therapy, such as the application of Carnoy's solution or decompression before enucleation, was reported to have recurrence rates of 1% to 8.7%. CONCLUSIONS: Although the existing literature consists of retrospective consecutive case series, it appears that resection or enucleation with adjunctive therapy is associated with recurrence rates that are lower than those associated with enucleation alone. Medline
1999 Bruins HH, Jolly DE, Koole R Preradiation dental extraction decisions in patients with head and neck cancer Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 88(4): 406-12 cancer decision surgery


1999 Hawkins R J, Wang E E, Leake JL Preventive health care, 1999 update: prevention of oral cancer mortality. The Canadian Task Force on Preventive Health Care J Can Dent Assoc 1999; 65(11): 617 Cancer BACKGROUND: Approximately 3,000 new cases of oral cancer are diagnosed each year in Canada. Most of these cases occur among older adults with a history of tobacco use or excessive alcohol consumption. Preventive interventions for oral cancer include counselling of patients to modify risk factors and screening to identify precancerous and early-stage lesions. This report presents evidence-based guidelines on the prevention of oral cancer and precancer among asymptomatic patients. METHODS: Literature searches of the 1966-1999 MEDLINE and CANCERLIT databases were completed using the major MeSH heading mouth neoplasms. References from articles and recommendations of organizations were also reviewed. The evidence-based methods of the Canadian Task Force on Preventive Health Care were used to assess evidence and to develop guidelines. Advice from experts and other recommendations were taken into consideration. RESULTS: In cohort and case-control studies, smoking cessation decreased the risk of oral cancer and precancer. Randomized controlled trials (RCTs) indicate counselling by trained health care professionals is effective in promoting smoking cessation. Although counselling has been effective for the reduction of excessive alcohol consumption in RCTs, no studies have examined whether alcohol reduction reduces the risk of oral cancer or precancer. The usefulness of general population screening is limited by the low prevalence and incidence of the disease, the potential for false-positive diagnoses and the poor compliance with screening and referral. There is no evidence that screening of the general population or high-risk groups leads to a reduction in mortality or morbidity from oral cancer. INTERPRETATION: There is good evidence to specifically consider smoking cessation counselling in a periodic health examination (grade A recommendation). For population screening, there is fair evidence to specifically exclude screening for oral cancer (grade D recommendation). For opportunistic screening during periodic examinations, there is insufficient evidence to recommend inclusion or exclusion of screening for oral cancer (grade C recommendation). For patients at high risk, annual examination by physician or dentist should be considered. Risk factors include tobacco use and excessive consumption of alcohol. These recommendations are similar to those made by the Canadian Task Force on the Periodic Health Examination in 1994 and by the U.S. Preventive Services Task Force in 1996. Medline J Can Dent Assoc
1998 Bruins HH, Koole R, Jolly DE Pretherapy dental decisions in patients with head and neck cancer. A proposed model for dental decision support Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 86(3): 256-67 cancer decision


1997 Meurman JH, Pyrhonen S, Teerenhovi L, Lindqvist C Oral sources of septicaemia in patients with malignancies. Oral Oncol 1997; 33(6): 389-97 Cancer This article reviews papers dealing with oral infections of adult septicaemia patients, searched from MEDLINE, Current Contents and Core Biomedical Collection databases from January 1966 to November 1996. Case reports were excluded. The systematic review of literature revealed that our knowledge of the topic is mostly based on very small patient material. There are no multicentre studies on the effects of various oral health treatment modes on the prevention of septicaemia of oral origin. The number of controlled and comparative studies on the efficacy of the different treatment protocols of oral infections is also small. Current recommendations in this respect are mainly empirical and not evidence based. Clinical practice guidelines are therefore urgently needed. Nevertheless, close co-operation between oncological and oral health units is emphasised because many studies have shown that the oral cavity is indeed an important source of bacteraemia. Life-threatening infections may follow if maintenance of oral health is neglected during anticancer therapy and if potential oral infection foci are left untreated before immunosuppressive therapy. Medline
1996 Madeya ML Oral complications from cancer therapy: Part 1--Pathophysiology and secondary complications & Part 2--Nursing implications for assessment and treatment Oncol Nurs Forum 1996; 23(5): 801-19 cancer


1989 Rosenberg D, Cretin S Use of meta-analysis to evaluate tolonium chloride in oral cancer screening Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1989; 67: 621-7 Cancer