| aar | Authors | Title | Source | Topics | abstract | pubmedtext | fulltext |
|---|---|---|---|---|---|---|---|
| 2003 | Beikler T, Flemmig TF | Implants in the medically compromised patient | Crit Rev Oral Biol Med 2003; 14(4): 305-16 | implants medicine | |||
| 2002 | Joshipura K | The relationship between oral conditions and ischemic stroke and peripheral vascular disease | J Am Dent Assoc 2002; 133 Suppl: 23S-30S | medicine | |||
| 2002 | Bader JD, Bonito AJ, Shugars DA | A systematic review of cardiovascular effects of epinephrine on hypertensive dental patients | Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 93(6): 647-53 | Medicine Pharmaceutical | OBJECTIVE: A systematic review was conducted to identify any additional risks of adverse cardiovascular outcomes to hypertensive individuals represented by use of epinephrine-containing anesthetic solutions and epinephrine-impregnated retraction cords. STUDY DESIGN: Two searches identified 373 local anesthetic and 33 retraction cord reports; 6 local anesthetic reports met inclusion criteria. RESULTS: Use of epinephrine in uncontrolled hypertensive patients was associated with small, nonsignificant increases in systolic and diastolic blood pressure. No adverse outcomes were reported. Only one study examined effects of epinephrine on controlled hypertensive patients, in whom additional risks due to interactions with antihypertensive medication are possible. Available studies did not address effects of gingival retraction cord on hypertensive patients. CONCLUSIONS: Although the increased risk for adverse events among uncontrolled hypertensive patients was found to be low and the reported occurrence of adverse events in hypertensive patients associated with the use of epinephrine in local anesthetics was minimal, the quantity and quality of the pertinent literature is problematic | Medline | |
| 2002 | Bjelland S, Bray P, Gupta N, Hirscht R | Dentists, diabetes and periodontitis. | Aust Dent J 2002; 47(3): 202-7 | Medicine Periodontics | |||
| 2001 | Agency for Healthcare Research and Quality Agency for Healthcare Research and Quality (AHRQ) 2001 | Cardiovascular Effects of Epinephrine on Hypertensive Dental Patients - systematic review. | Agency for Healthcare Research and Quality (AHRQ) 2001 | Medicine | Nishimura K, Rasool F, Ferguson MB, Sobel M, Niederman R. Benchmarking the clinical prosthetic dental literature on MEDLINE. J Prosthet Dent. 2002 Nov;88(5):533-41. Park J, Niederman R. MEDLINE's identification of randomized control trials in pediatric dentistry. J Clin Pediatr Dent. 2002 Summer;26(4):395-9. Yang S, Needleman H, Niederman R. A bibliometric analysis of the pediatric dental literature in MEDLINE. Pediatr Dent. 2001 Sep-Oct;23(5):415-8. Kim MY, Lin J, White R, Niederman R. Benchmarking the endodontic literature on MEDLINE. J Endod. 2001 Jul;27(7):470-3. Russo SP, Fiorellini JP, Weber HP, Niederman R. Benchmarking the dental implant evidence on MEDLINE. Int J Oral Maxillofac Implants. 2000 Nov-Dec;15(6):792-800. |
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| 2001 | Sutherland SE, Browman GP | Prophylaxis of oral mucositis in irradiated head-and-neck cancer patients: a proposed classification scheme of interventions and meta-analysis of randomized controlled trials | Int J Radiation Oncol Biol Physics 2001; 49(4): 917-930 | Cancer Medicine Mucosa | PURPOSE: To identify, classify, and evaluate agents used in the prophylaxis of oral mucositis in irradiated head and neck cancer patients. METHODS: Data sources included multiple databases and manual citation review of relevant literature. Based on the eligibility criteria, 59 studies were independently reviewed by two reviewers. Forty-two studies were included in the classification scheme, of which 15 met the criteria for inclusion in the meta-analysis. Data were extracted by duplicate independent review, with disagreement resolved by consensus. RESULTS: Overall, the interventions reduced the odds of developing severe oral mucositis, when assessed by clinicians, by 36% (OR: 0.64; 95% CI: 0.46, 0.88). Subgroup analysis suggested that only the narrow-spectrum antibacterial lozenges were effective (OR: 0.45; 95% CI: 0.23, 0.86); however, the power of the aggregated data in the other classes may have been insufficient to detect differences. When the outcome was assessed by patients, no significant difference was seen in the outcome between the treatment and the control groups (OR: 0.79; 95% CI: 0.56-1.12). CONCLUSIONS: Overall, interventions chosen on a sound biologic basis to prevent severe oral mucositis are effective. In particular, when oral mucositis is assessed by clinicians, narrow-spectrum antibiotic lozenges appear to be beneficial. Methodologic limitations were evident in many of the studies. Further research using validated measurement tools in larger, methodologically sound trials is warranted. | Medline | Elsevier |
| 2001 | Garcia RI, Nunn ME, Vokonas PS | Epidemiologic associations between periodontal disease and chronic obstructive pulmonary disease. | Ann Periodontol 2001; 6(1): 71-7 | Medicine Periodontics | The nature of the relationship of periodontal disease to a number of systemic health outcomes, including chronic obstructive pulmonary disease (COPD), remains unclear. Various causal mechanisms have been proposed to explain the observed epidemiologic associations between periodontal diseases and respiratory diseases. We have reviewed the epidemiologic and clinical evidence for this association. The methodologic approach we have taken is based on a structured systematic review of the indexed biomedical literature on these subjects. The primary focus of this review was on the analysis of periodontal health status measures and their association with COPD, which includes chronic bronchitis and emphysema. We found that a paucity of published results exist on this specific relationship and those which do exist typically represent secondary analyses of existing data sets. Nevertheless, the epidemiologic evidence identified in this systematic review indicates that worse periodontal health status is associated with an increased risk of COPD, with odds ratios ranging from 1.45 to 4.50 (significant at the 95% confidence interval). However, it is possible that residual confounding by tobacco smoking may account in part for the observations. A causal association between periodontal health status and risk of COPD, although biologically plausible, remains speculative. Randomized controlled trials will be required in order to address the question of causality and to better understand the biological basis of these epidemiologic associations. | Medline | |
| 2001 | Taylor GW | Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. | Ann Periodontol 2001; 6(1): 99-112 | Medicine Periodontics | This review evaluates evidence for a bidirectional relationship between diabetes and periodontal diseases. A comprehensive Medline search of the post-1960 English language literature was employed to identify primary research reports of relationships between diabetes and periodontal diseases. Reports included in the review on the adverse effects of diabetes on periodontal health (DM-->PD) were restricted to those comparing periodontal health in subjects with and without diabetes. Review of adverse affects of periodontal infection on glycemic control included reports of periodontal treatment studies and follow-up observational studies in which changes in glycemic control could be assessed. Observational studies reporting DM-->PD provided consistent evidence of greater prevalence, severity, extent, or progression of at least one manifestation of periodontal diseases in the large majority of reports (supportive evidence in 44/48 total reviewed; 37/41 cross-sectional and 7/7 cohort). Additionally, there were no studies reviewed with superior design features to refute this association. Treatment studies provided direct evidence to support periodontal infection having an adverse, yet modifiable, effect on glycemic control. However, not all investigations reported an improvement in glycemic control after periodontal treatment. Additional evidence to support the effect of severe periodontitis on increased risk for poorer glycemic control comes from 2 follow-up observational studies. The evidence reviewed supports viewing the relationship between diabetes and periodontal diseases as bidirectional. Further rigorous, systematic study is warranted to establish that treating periodontal infections can be influential in contributing to glycemic control management and possibly to the reduction of the burden of complications of diabetes mellitus. | Medline | |
| 2000 | Armitage GC | Periodontal infections and cardiovascular disease--how strong is the association? | Oral Dis 2000; 6(6): 335-50 | Medicine Periodontics | In the past decade there has been renewed interest in the old hypothesis that infections increase the risk of developing cardiovascular disease and stroke. There is now a convincing body of evidence that atherosclerosis has a major inflammatory component and is much more than the simple vascular accumulation of lipids. Infectious agents that have been linked to an increased risk of coronary heart disease (CHD) include Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpesviruses. The concept has emerged that each of these agents is an independent risk factor for CHD and that common chronic infections are important. In addition, periodontal infections have also been implicated as one of several factors contributing to the development of CHD. Evidence supporting a causative role of chronic infections in CHD is largely circumstantial. However, the evidence is sufficiently strong to warrant further examination of the possible link between chronic infections and CHD. In this review the lines of evidence for a causative role of C. pneumoniae in the development of CHD are summarized and contrasted with the lines of evidence suggesting a periodontal infection--CHD association. If common or widespread chronic infections are truly important risk factors for CHD, it is unlikely that a single infection will be shown to be causative. It is likely that the entire microbial burden of the patient from several simultaneous chronic infections is more important (e.g., H. pylori-caused gastric ulcers + C. pneumoniae-caused bronchitis + periodontitis). Increased cooperation between cardiologists and periodontists will be required to determine if, and what, combinations of common chronic infections are important in the pathogenesis of CHD and stroke. | Medline | |
| 2000 | Allen IE, Monroe M, Connelly J, Cintron R, Ross SD | Effect of postmenopausal hormone replacement therapy on dental outcomes: systematic review of the literature and pharmacoeconomic analysis. | Manag Care Interface 2000; 13(4): 93-9 | Medicine | A systematic review and economic analysis of clinical trials evaluating the effect of hormone replacement therapy (HRT) on dental outcomes in postmenopausal women were conducted. Twenty published studies involving more than 13,735 postmenopausal women were summarized and analyzed. In prospective studies, the effect of HRT on osteoporosis (OP) has been well documented. The effect of OP on mandibular bone density has also been examined in some observational studies. Few studies, however, have examined the effect of HRT directly on mandibular bone density or on dental outcomes. From these studies, the effect of HRT on costs of dental treatment and prophylaxis was estimated directly and indirectly. It was determined that HRT use was associated with reduction in adverse dental outcomes and the associated costs of dental care. Annualized excess cost in a cohort of 1,000 untreated women averaged $100,000. From this analysis, it is clear that postmenopausal women with OP who do not receive HRT have a greater incidence of adverse dental outcomes and higher dental care costs than those who do. | Medline | |
| 1999 | Danesh J | Coronary heart disease, Helicobacter pylori, dental disease, Chlamydia pneumoniae, and cytomegalovirus: meta-analyses of prospective studies. | Am Heart J 1999; 138(5 pt2): 434-437 | Medicine | - | Medline | |
| 1998 | Seymour RA, Steele JG | Is there a link between periodontal disease and coronary heart disease? | Br Dent J 1998; 184(1): 33-8 | Medicine Periodontics | OBJECTIVE: To provide a critical review of the studies completed to date that have investigated a link between coronary heart disease and dental health. DESIGN: Retrospective analysis. SETTING: Mainly hospital-based patients or subjects involved in longitudinal health care studies. MAIN OUTCOME MEASURES: The incidence of coronary heart disease and its relationship to dental health and other recognised risk factors. RESULTS: Evidence suggests that dental health, in particular periodontal disease, may be a significant risk factor for coronary heart disease and further coronary events. Possible biological mechanisms that link the two diseases are appraised. CONCLUSIONS: There does appear to be increasing evidence that a relationship exists between dental health and coronary heart disease, especially in males aged 40-50 years. The presence of a hyperinflammatory monocyte phenotype may provide a common biological mechanism that links the two diseases. | Medline |